Abstract
The small vessel blood volume of the brain is an important factor in cerebral hemodynamics and metabolism, but it is difficult to study. A study of regional blood volume in small animals is complicated by rapid changes in volume. These can occur in less than one second. The use of rapid coagulation of the blood to stimate the amount of blood present provides a simple method to measure volume ithout the use of anesthetics and with minimal stress to the animal. Acute reatment of mice with 0.20 mg/kg, i.V., dihydroergotoxin mesylate (Hydergine) suited in no change in blood volume one minute after treatment. After mice msumed about 1 mg/kg of dihydroergotoxin mesylate per day for 11 days in their rinking water, an increase in blood volume which was not significant was found n seven of eight regions of the brain. Blood volume in the cerebral cortex, owever, increased significantly. It is reasonable to propose that the effective terapeutic response of senile patients to this drug stems from increased blood volume in the brain. These changes in blood volume in a specific region of the brain, found only after sustained drug therapy, support and reinforce clinical reports of a delayed response to therapy with dihydroergotoxin mesylate.
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