Contribution of Locomotor Activity to Change in Cerebellar Cyclic GMP Following Administration of Drugs

Abstract

Numerous drugs and stressors have been reported to affect cerebellar cyclic GMP. We have previously demonstrated that locomotor activity independent of stress increases cyclic GMP in cerebellum and other brain regions. In the present study, we examined the effects of immobilization on the increases in cerebellar cyclic GMP induced by cold exposure or apomorphine. We found that immobilization attenuated the elevations in cerebellar cyclic GMP after either cold exposure or injection of apomorphine. We suggest that locomotor activity may be an intervening variable in producing changes in cerebellar cyclic GMP attributed to drugs or other environmental stimuli.