Abstract
Erythrina indica widely known as 'Indian coral tree' belongs to the family Fabaceae. It is used in the traditional medicine for treatment of inflammation, joint pain, acute and chronic dysentery [1]. Aqueous extract of leaves Erythrina indica (EIA) was studied for its anti-inflammatory potential using in vitro models viz. albumin denaturation, membrane stabilization and proteinase inhibitory action [2]. In vivo anti-inflammatory activity was studied at the dose of 125, 250 and 500mg/kg using carrageenan, histamine, serotonin induced paw edema [2] and cotton pellet induced granuloma formation in rats [3]. EIA showed significant (P<0.05) protection against denaturation of proteins and heat induced Red Blood Cells (RBCs) damage. It also exhibited significantly anti-proteinase activity which plays an important role in the development of tissue damage during inflammatory reactions. EIA showed significant decrease in carrageenan induced rat paw edema, a test which has a significant predictive value for anti-inflammatory agents acting by inhibiting the mediators of acute inflammation. It also effectively inhibited the inflammation induced by histamine, and serotonin which suggest that the anti-inflammatory activity of EIA is possibly mediated by inhibiting the action of these mediators. It showed the significant activity in chronic proliferative phase of the inflammatory process by decrease in the weight of granuloma formation in rats. It is concluded that, aqueous extract of leaves Erythrina indica exhibited significant dose dependent in vitro and in vivo anti-inflammatory activity.
Published Version
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