STUDY OF CEREBROPROTECTIVE EFFICIENCY OF ADEMOL AND MAGNESIUM SULPHATE IN EXPERIMENTAL MODEL OF THE TRAUMATIC BRAIN INJURY

Abstract

Objective - сompare the effectiveness of adamantane derivative 1-adamantyletylox-3-morpholino-2-propanol hydrochloride (Ademol) and magnesium sulfate for the correction of mystic function and neurological deficit in a rat model of traumatic braininjury.Material and methods. The therapeutic effect of Ademol on simulated traumatic braininjury was assessed using doses of 1, 2 and 4 mg/kg. Pseudo-operated animals received a0,9% solution of NaCl at the rate of up to the volume of the most effective dose of Ademol.As a drug for the control group, 0,9% NaCl solution was used at a dose of 2 ml/kgintravenous in the same regimen. Neurological deficit in rats with traumatic brain injurywas assessed on the first day and at the end of the acute period (on the eighth day) usingthe stroke-index C.P. McGrow. The ability of animals to learn and memorize an aversivestimulus was investigated in a passive avoidance conditional response test. Thetechnique is based on the innate instinct of rats to a limited darkened space. Preservation of the conditioned reaction was checked after 24 hours by the change in thelatent time of entry of the rat into the dark compartment. Also noted The number ofanimals that tried to enter the dark chamber, but did not complete the attempt was alsonoted.Results. Investigating the effect of course therapy with Ademol solution on the degree ofneurological deficit reduction, it can be noted that this property of the studied drug wasdominated by magnesium sulfate solution in the first day of application 24% and on theeighth day 30% (p <0,05). In restoring mental functions in traumatic brain injury, eightday rat therapy with magnesium sulphate solution somewhat improved memory, but wasinferior in performance to Ademol, which approached the test results of the passiveavoidance conditional test to the results of pseudo-operated animals.Conclusion. The results, obtained for the correction of neurological deficit, make itpossible to assert that there is no reliable efficacy of using magnesium sulfate inexperimental traumatic brain injury in rats. Ademol, in contrast to magnesium sulfatesolution, contributed to a reduction in the severity of neurological disorders, which wasaccompanied by an improvement in the mental functions in animals on the eighth day oftraumatic brain injury.