Abstract
Objective To explore the relationship between transmembrane 7 superfamily member 4 (TM7SF4) gene and breast cancer signal pathway of proliferation, invasion and metastasis. Methods After downexpressed TM7SF4 gene in michigan cancer foundation-7 (MCF-7) breast cell, screening high correlation functional gene and signal pathway by Real-time quantitative polymerase chain reaction array (qPCR array). Results After down-expressed TM7SF4 gene, there were 17 differentially expressed genes in screened 91 genes, TM7SF4 was closely related to 5 genes in the 17 kinds of differentially expressed genes using gene enrichment analysis. TM7SF4 geng was also related to tripartite motif protein family 24 (TRIM24) and tumor suppressor protein (TP53). In TRIM24 gene sets, CD44 variant 6 (CD44v6), cyclin dependent kinase inhibitor 1A (CDKN1A), Caspase-1 (CASP1) and insulin like growth factor 2 (IGF2) were obviously increased by TRIM24 signal pathway (P=0.006, 0.001, 0.002, 0.001); In TP53 gene sets, B-cell lymphoma-2 (bcl-2)-associated X (bax), CDKN1A and CASP1 were significantly increased by TP53 signal pathway (P=0.004, 0.001, 0.002). Conclusion TM7SF4 gene develops its role by TRIM24 and TP53 signal pathways in breast cancer cell line. Key words: Real-time quantitative polymerase chain reaction array; Breast cancer; Signal pathway
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
