Studies relative to the chemotherapy of bacterial endocarditis.

Abstract

Article1 November 1950STUDIES RELATIVE TO THE CHEMOTHERAPY OF BACTERIAL ENDOCARDITISM. H. NATHANSON, M.D., F.A.C.P., RUTH A. LIEBHOLDM. H. NATHANSON, M.D., F.A.C.P.Search for more papers by this author, RUTH A. LIEBHOLDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-33-5-1224 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe introduction of a successful therapeutic agent in a disease often leads to clarification of the nature of that disease. This is illustrated by the progress that has been made in the elucidation of the nature of diabetes mellitus since the advent of insulin, and the similar progress in the understanding of various diseases of the blood following the introduction of liver therapy.In the case of subacute bacterial endocarditis, the uniformly fatal character of the disease prior to the use of penicillin and the failure of various therapeutic agents have not been adequately explained. The low virulence of the...Bibliography1. Friedman M: A study of the fibrin factor in its relation to subacute endocarditis, J. Pharmacol. and Exper. Therap. 63: 173, 1938. Google Scholar2. Friedman M: Use of sulfanilamide and sulfapyridine in therapy of subacute bacterial endocarditis, Arch. Int. Med. 67: 921, 1941. CrossrefGoogle Scholar3. DuncanFaulkner CNJM: Penetration of blood clot by sulfanilamide, sulfapyridine, sulfathiazole and sulfamethylthiazole, Am. J. M. Sc. 200: 492, 1940. CrossrefGoogle Scholar4. NathansonLiebhold MHRA: Diffusion of sulfonamides and penicillin into fibrin, Proc. Soc. Exper. Biol. and Med. 62: 83, 1946. CrossrefMedlineGoogle Scholar5. FosterWoodruff JWHB: Microbiological aspects of penicillin, J. Bact. 47: 43, 1944. CrossrefMedlineGoogle Scholar6. PriestMcGee WSCJ: Streptomycin in the treatment of subacute bacterial endocarditis, J. A. M. A. 132: 124, 1946. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Los Angeles, California*Received for publication October 14, 1948.From the University of Southern California, School of Medicine; and Research Laboratories, Cedars of Lebanon Hospital.This study has been carried out with the support of the Dorothy H. and Lewis Rosenstiel Foundation. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAnimal models of endocarditisPHARMACOKINETIC AND PHARMACODYNAMIC ASPECTS OF THERAPY OF EXPERIMENTAL ENDOCARDITISPharmacokinetic and pharmacodynamic requirements for antibiotic therapy of experimental endocarditisAntimicrobial chemotherapy in the dog.Erkrankungen des EndokardShort-term penicillin and dihydrostreptomycin therapy of streptococcal endocarditisDie Herz- und GefäßkrankheitenDas ResistenzproblemDie Therapie der Endocarditis lenta und ihre GrundlagenBacterial endocarditis 1 November 1950Volume 33, Issue 5Page: 1224-1231KeywordsBacterial diseasesChemotherapyDiabetes mellitusEndocarditisHospital medicineInsulinLiverLiver diseasesPenicillinResearch laboratories ePublished: 1 December 2008 Issue Published: 1 November 1950 PDF downloadLoading ...