TREATMENT OF SUBACUTE BACTERIAL ENDOCARDITIS WITH PENICILLIN: REPORT OF CASES TREATED WITHOUT ANTICOAGULANT AGENTS

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Article1 October 1945TREATMENT OF SUBACUTE BACTERIAL ENDOCARDITIS WITH PENICILLIN: REPORT OF CASES TREATED WITHOUT ANTICOAGULANT AGENTSJESSAMINE R. GOERNER, M.D., ARTHUR J. GEIGER, M.D., FRANCIS G. BLAKE, M.D., F.A.C.P.JESSAMINE R. GOERNER, M.D.Search for more papers by this author, ARTHUR J. GEIGER, M.D.Search for more papers by this author, FRANCIS G. BLAKE, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-23-4-491 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe attempt to cure subacute bacterial endocarditis with penicillin was a natural sequel to similar earlier efforts with the sulfonamide group of drugs, with which the results had proved successful in sporadic cases.1Limiting factors in the control of the infection with the sulfonamides have included the resistance of the usual causative organism, theStreptococcus viridans, and the toxicity of the sulfonamide compounds when administered in the large doses and long courses required to achieve prolonged bacteriostatic concentrations in the body. Although the resistance of theStreptococcus viridansto penicillin is generally known to be relatively high as compared with...Bibliography1. LICHTMAN SS: Treatment of subacute bacterial endocarditis: current results, Ann. Int. Med., 1943, xix, 787. Google Scholar2. LOEWEROSENBLATTGREENERUSSELL LPHJM: Combined penicillin and heparin therapy of subacute bacterial endocarditis, Jr. Am. Med. Assoc., 1944, cxxiv, 144. CrossrefGoogle Scholar3. KIRBY WM: Stability of penicillin solutions at room and incubator temperatures, Jr. Am. Med. Assoc., 1945, cxxv, 628. Google Scholar4. VON GLAHNPAPPENHEIMER WCAM: Relationship between rheumatic and subacute bacterial endocarditis, Arch. Int. Med., 1935, lv, 173. CrossrefGoogle Scholar5. LICHTMANGROSS SSL: Streptococci in the blood in rheumatic fever, rheumatoid arthritis and other diseases, Arch. Int. Med., 1932, xlix, 1078. CrossrefGoogle Scholar6. LIBMAN E: A further report on recovery and recurrence in subacute bacterial endocarditis, Trans. Assoc. Am. Phys., 1933, xlviii, 44. Google Scholar7. LOEWE L: The combined use of anti-infectives and anticoagulants in the treatment of subacute bacterial endocarditis, Bull. New York Acad. Med., 1945, xxi, 59. Google Scholar8. LOEWE L: Personal communication. Google Scholar9. DAWSONHUNTER MHTH: The treatment of subacute bacterial endocarditis with penicillin. (Results in twenty cases), Jr. Am. Med. Assoc., 1945, cxxvii, 129. CrossrefGoogle Scholar10. KELSONWHITE SRPD: A new method of treatment of subacute bacterial endocarditis using sulfapyridine and heparin in combination: Preliminary Report, Jr. Am. Med. Assoc., 1939, cxiii, 1700. Google Scholar11. MCLEANMEYERGRIFFITH JBBJM: Heparin in subacute bacterial endocarditis, Jr. Am. Med. Assoc., 1941, cxvii, 1870. CrossrefGoogle Scholar12. KATZELEK LNSR: Combined heparin and chemotherapy in subacute bacterial endocarditis, Jr. Am. Med. Assoc., 1944, cxxiv, 149. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New Haven, Connecticut*Received for publication June 14, 1945.From the Department of Internal Medicine, Yale University School of Medicine, New Haven, Conn., and the Medical Service of the New Haven Hospital. Nextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAntimicrobial treatment of infective endocarditis caused by viridans streptococci highly susceptible to penicillin: historic overview and future considerationsTreatment of pneumococcal pneumonia: the case for penicillin GFAILURE OF "ADEQUATE" PENICILLIN THERAPY TO PREVENT BACTERIAL ENDOCARDITIS AFTER TOOTH EXTRACTIONPORTACAVAL SHUNT IN FAMILIAL HYPERCHOLESTEROLÆMIAThe persistence of penicillin G in the mammary gland when infused immediately after the last milking of lactationSUBACUTE BACTERIAL ENDOCARDITIS OCCURRING IN A PATIENT RECEIVING ORAL PENICILLIN AS PROPHYLAXIS AGAINST RHEUMATIC FEVER*DONALD S. DOCK, M.D., LUCIEN B. 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DONEGAN, M.D.Subacute bacterial endocarditisStreptomycin in the Treatment of Bacterial EndocarditisAcute puerperal mastitisProlonged administration of penicillin in arthritisEffect of penicillin on the bacteremia following dental extractionThe treatment of subacute bacterial endocarditis with penicillin in beeswax-peanut oil: Gluteal abscesses and rupture of the spleenBacterial Endocarditis Treated with PenicillinPENICILLIN TREATMENT OF SUBACUTE BACTERIAL ENDOCARDITISThe use of penicillin in the treatment of subacute bacterial endocarditis in childrenThe treatment of subacute bacterial endocarditis with antibioticsThe Treatment of Bacterial EndocarditisThe Heart in Rheumatic Fever 1 October 1945Volume 23, Issue 4Page: 491-519KeywordsBloodEndocarditisFeversHospital medicineMedical servicesPenicillinStreptococcal infectionsStreptococcusSulfonamideToxicity ePublished: 1 December 2008 Issue Published: 1 October 1945 Copyright & PermissionsCopyright, 1945, by The American College of PhysiciansPDF downloadLoading ...