Abstract
The influence of several naphthalene and furan derivatives which are potent singlet oxygen ( 1O 2) acceptors on two prostaglandin synthetase preparations derived from bovine seminal vesicles or rat kidney medulla was studied. Also the effects on the formation of superoxide anion radicals (O 2 −. ) were measured to give further evidence for or against the possible involvement of 1O 2 or O 2 −. in the cyclo-oxygenase reaction. The data we have attained make an essential role of these activated oxygen species as initiators of the cyclooxygenase reaction unlikely and thereby support the hypothesis that cyclo-oxygenation during prostaglandin biosynthesis is a lipoxygenase type of reaction.
Published Version
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