Studies on the invitro anticancer activity of mangostin and acetylated mangostin against MCF-7 cell lines

Abstract

The naturally occurring xanthone, α-mangostin and γ-mangostin were isolated using column chromatographic method from pericarp of Garcinia mangostana L. ( Clusiaceae ). These isolated vital secondary metabolites α-mangostin and γ-mangostin when subjected to acetylation yielded di-acetylated α-mangostin and tri-acetylated γ-mangostin respectively. The parent α-mangostin and γ-mangostin along with its acetylated compounds were analyzed for its cytotoxicity properties against MCF-7 cell lines (human breast adenocarcinoma) using MTT assay. The results indicated that, the di-acetyl-α-mangostin and tri-acetyl-γ-mangostin products showed two and three fold increase in cytotoxic potential with IC 50 4.55 µM and 2.87 µM respectively compared to the parent compounds.