GC-MS Analysis for Leaf Extract of Suaeda nudiflora and Screening of Their Invitro Antiproliferative Effect Against MCF 7 and HeLa cells

Abstract

In the present study, bioactive compounds from methanol leaf extracts of Suaeda nudiflora were identified by GC-MS analysis. The spectral properties of GC-MS separated compounds were found to be terpenoids, di-terpenes, phytol and fatty acids. Further, the potential of methanol extracts of S. nudiflora was screened for its anticancer activity using the cancer cell lines namely: human breast adeno carcinoma (MCF7) and human cervical cancer (HeLa). The MTT assay results revealed that cytotoxicity due to methanol extract against MCF7 and HeLa cell lines were found to be statistically significant and the viability of cell lines was reduced to 36.72 % and 32.64 % respectively. The study proved that the leaf extract of S. nudiflora was found to be more effective against HeLa cell lines in comparision with MCF 7 cell lines.