Abstract
Normal human gastric juice, heated normal gastric juice and neutralized normal gastric juice have been administered to adult male rats by gastric intubation, without producing any consistent or predictable changes in the number of circulating reticulocytes. Intramuscular injections of gastric juice and gastric juice concentrates did not produce reticulocyte responses which could not be ascribed to irritation and tissue destruction. The nonspecific character of reticulocyte responses in the rat has been emphasized and the normal lability of the reticulocyte level pointed out. The reticulocyte response in rats has not proved in our hands a reliable method for detecting the presence of antianemic substances.
Published Version
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