1. Peptic ulcer disappearance after feedings of normal human gastric juice

Abstract

1. The gastric juice of normal volunteer subjects was fed to a series of patients with uncomplicated peptic ulcer. The normal gastric juice was neutralized, filtered and preserved with tricresol. 2. The relief of peptic ulcer symptoms and prompt roentgen disappearance of peptic ulcer is herein recorded following the feeding of gastric juice from normal human subjects. 3. Evidence is presented which tends to indicate that a “protective principle” is elaborated within the gastric and duodenal mucous membranes and secreted into the gastric juice. This protective principle may be lacking or be impaired in patients with peptic ulcer. 4. It appears that the protective principle in normal gastric juice can be fed to uncomplicated peptic ulcer patients causing the ulcers and symptoms in these patients to disappear.