Studies on EAAT4 glutamate transporter during early neural development

Abstract

Event Abstract Back to Event Studies on EAAT4 glutamate transporter during early neural development Mate Neubrandt1*, M. Jelitai1, B. Varga1 and Emilia Madarasz1 1 Institute of Experimental Medicine, Hungarian Academy of Sciences, Hungary Excitatory amino acid transporters (EAATs) are known to function as glutamate carriers. To date, five distinct plasma membrane glutamate transporters have been described in mammalian cells (GLAST, GLT1, EAAC1, EAAT4, EAAT5), with different spatial and cellular distribution. In the present work we examined the expression and role of glutamate transporters in the course of early neurogenesis. The data indicate that GLAST and EAAT4 mRNAs are present in neural stem cells. The early expression of GLAST is well known, but the expression of EAAT4 during embryonic development has not been described. We demonstrated the presence of the EAAT4 protein in two different stem cell lines (NE-4C, P19) and the transporter function of EAAT4 was also proved in neural stem cells. The presence of EAAT4 transporter was also examined in vivo at different developmental stages. Immunohistochemical studies on developing rodent brain revealed, that EAAT4 is present in neural progenitors in the embryonic (E15) mouse brain and in astroglial progenitor cells in the perinatal (P1) rat brain. The data suggest some specific roles of EAAT4 transporter in fate determination of neural stem cells but its exact function is far from clear. Conference: 12th Meeting of the Hungarian Neuroscience Society, Budapest, Hungary, 22 Jan - 24 Jan, 2009. Presentation Type: Poster Presentation Topic: Developmental neurobiology and subcortical functions Citation: Neubrandt M, Jelitai M, Varga B and Madarasz E (2009). Studies on EAAT4 glutamate transporter during early neural development. Front. Syst. Neurosci. Conference Abstract: 12th Meeting of the Hungarian Neuroscience Society. doi: 10.3389/conf.neuro.01.2009.04.070 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 02 Mar 2009; Published Online: 02 Mar 2009. * Correspondence: Mate Neubrandt, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary, neubrandt@koki.hu Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Mate Neubrandt M. Jelitai B. Varga Emilia Madarasz Google Mate Neubrandt M. Jelitai B. Varga Emilia Madarasz Google Scholar Mate Neubrandt M. Jelitai B. Varga Emilia Madarasz PubMed Mate Neubrandt M. Jelitai B. Varga Emilia Madarasz Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.