Structural and release properties of amylose inclusion complexes with ibuprofen

Abstract

Complexes of amylose (AS) with ibuprofen (IBF) were prepared by the acidification method to yield V-type structure with different IBF-AS ratios. Among the ratios being tested, the IBF-AS ratio of 1/10 gave the highest yields (52.6%, w/w) and IBF content in the complex (14.1%, w/w). The XRD and 13C CP/MAS NMR spectra indicated that the AS and IBF formed the V-amylose complexes. The DSC and FT-IR analysis further testified the formation of the AS-IBF inclusion complexes. These complexes are stable in simulated gastric fluid (pH 1.2), with <5.5% of the complexed IBF. All complexes show sustained release characteristics in simulated small intestinal fluid (pH 7.2). It is evident that the ibuprofen cumulative release of complexes increased with the increase of IBF-AS ratios. Therefore, the AS-IBF complexes can be used as intestinally targeted and slow releasing drugs based on the action of enzymatic hydrolysis of AS.