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Abstract
Abtract Background: Stroke is an international health problem with high associated human and economic costs. Stroke burden is expected to be rising, especially in developing countries. The mortality rate from stroke in Russia is one of the highest in the world. Epidemiological evidence suggests that binge drinking is an important determinant of high stroke mortality rate in Russia. In line with this evidence we assume that devastating combination of higher level of alcohol consumption per capita and binge drinking of vodka results in a close association between binge drinking and stroke mortality at the aggregate level in Russia. This paper was design to estimate the aggregate level effect of binge drinking on stroke mortality rate in Russian. Method: Trends in age-adjusted, sex-specific stroke mortality and fatal alcohol poisoning rate (as a proxy for binge drinking) from 1965 to 2005 were analyzed employing a distributed lags analysis in order to asses bivariate relationship between the two time series. Results: The results of the time series analysis indicates the presence of a statistically significant association between the two time series at zero lag for male (r = 0.76; S.E. = 0.17), and for female (r = 0.64; S.E. = 0.17). Conclusion: The results of present study support the hypothesis that alcohol played a crucial role in cerebrovascular mortality fluctuation in Russia over the past decades. This study also indicates that substantial proportion of stroke deaths in Russia is due to acute effect of binge drinking. The findings from the present study have important implications as regards cerebrovascular mortality prevention indicating that a restrictive alcohol policy can be considered as an effective measure of prevention in countries where higher rate of alcohol consumption and binge drinking pattern.
Highlights
Stroke is one of the major cause of death in the developed world and a top ten contributor to the global burden of disease (Donna, Fisher, Macleod & Davis, 2007)
Accumulated research evidence suggests that heavy alcohol consumption increases the relative risk of stroke, while light or moderate alcohol consumption may be protective against ischemic stroke (Djousse, Ellison, Beiser, Scaramucci, D’Agostino & Wolf, 2002; Patra, Taylor, Irving, Roerecke, Baliunas, Mohapatra & Rehm, 2010)
The meta-analysis of 35 observational studies published between 1966 and 2002 revealed that compared with abstainers, consumption of more than 60 g of alcohol per day was associated with an increased relative risk of total stroke, 1.64, ischemic stroke, 1.69, and hemorrhagic stroke, 2.18 (Reynolds, Lewis, Nolen, Kinney, Sathya & He, 2003)
Summary
Stroke is one of the major cause of death in the developed world and a top ten contributor to the global burden of disease (Donna, Fisher, Macleod & Davis, 2007). Alcohol has been identified as both a risk and a protective factor for stroke (Gorelic, 1987; Sacco, Elkind, Boden-Albala, Lin, Kargman, Hauser, Shea & Paik, 1999). Accumulated research evidence suggests that heavy alcohol consumption increases the relative risk of stroke, while light or moderate alcohol consumption may be protective against ischemic stroke (Djousse, Ellison, Beiser, Scaramucci, D’Agostino & Wolf, 2002; Patra, Taylor, Irving, Roerecke, Baliunas, Mohapatra & Rehm, 2010). The meta-analysis of 35 observational studies published between 1966 and 2002 revealed that compared with abstainers, consumption of more than 60 g of alcohol per day was associated with an increased relative risk of total stroke, 1.64 (95% CI, 1.39-1.93), ischemic stroke, 1.69 (95% CI, 1.34-2.15), and hemorrhagic stroke, 2.18 (95% CI, 1.48-3.20) (Reynolds, Lewis, Nolen, Kinney, Sathya & He, 2003)
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