Strategies to improve amiodarone bioavailability in post operative atrial fibrillation

Abstract

Bioactive compound found in medicinal plants are used to treat a variety of human ailments and serve a vital part in healing. M. calabura L. is a species of Muntingia. (M. calabura, Elaeocarpaceae) has long been utilized to treat a variety of pain-related issues. The goal of this study is to investigate at the phytochemicals, antioxidants, and antibacterial capabilities of M. calabura bark. By using the soxhlation extraction, the dried bark of M. calabura was successively extracted with n-hexane, ethyl acetate, and methanol solvents and the solvents from the extracts were evaporated under vacuum. The well-known test procedure was used to determine the qualitative analysis of various phytochemical elements as well as the quantitative analysis of total phenolic, flavonoids, and alkaloid content. The antioxidant activity of ethyl acetate and methanolic extracts bark was measured in vitro using the DPPH (2,2-diphenyl-1-picrylhydrazyl) model. The presence of numerous phytoconstituents in each extract was discovered through preliminary phytochemical analysis. To determine antimicrobial activity, a well diffusion method was used to test an ethyl acetate extract of M. calabura (bark) against three different strains, and it showed considerable inhibitory action against all of them. The present study concluded that the all the bark of M. calabura is a rich source of secondary phytoconstituents which impart significant antioxidant potential. The findings of the present study will be helpful to Phyto chemists, pharmacologists and pharmaceutical industries. Keywords: Arrhythmia, Atrial fibrillation, Amiodarone, transdermal, Liposome, Inclusion complex, Solid dispersion.