Abstract
In isolated 5-hydroxytryptamine organelles of platelets from rabbits, guinea pigs and rats as well as in chromaffin granules of bovine adrenal medulla, the molar ratios uronic acid/monoamines and hexosamines/monoamines were in general markedly less than one. Rabbits showed ratios as low as 0.00075 and 0.015 respectively. In organelles of guinea pig platelets the ratio hexosamines/5-hydroxytryptamine dropped from 0.65 to 0.05 if the organelles had been loaded with exogenous 5-hydroxytryptamine administered i.p. Whole platelets of rabbits and guinea pigs showed a markedly higher ratio uronic acid/5-hydroxytryptamine than the islated 5-hydroxytryptamine organelles. It is concluded that the major part of endogenous and exogenous monoamines present in storage organelles cannot be directly bound to the anionic sites of glycosaminoglycan chains.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
