Abstract
In isolated 5-hydroxytryptamine organelles of platelets from rabbits, guinea pigs and rats as well as in chromaffin granules of bovine adrenal medulla, the molar ratios uronic acid/monoamines and hexosamines/monoamines were in general markedly less than one. Rabbits showed ratios as low as 0.00075 and 0.015 respectively. In organelles of guinea pig platelets the ratio hexosamines/5-hydroxytryptamine dropped from 0.65 to 0.05 if the organelles had been loaded with exogenous 5-hydroxytryptamine administered i.p. Whole platelets of rabbits and guinea pigs showed a markedly higher ratio uronic acid/5-hydroxytryptamine than the islated 5-hydroxytryptamine organelles. It is concluded that the major part of endogenous and exogenous monoamines present in storage organelles cannot be directly bound to the anionic sites of glycosaminoglycan chains.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
