Abstract
This chapter presents the study conducted to investigate with the electron microscope the affinity of the nerve fibers and perikarya of the postganglionic neurons for some labeled biogenic amines or their precursors; the effects of some drugs on these properties were also studied. It also describes an attempt to apply the radioautographic method to the identification of the adrenergic fibers in the intestine, in which the usual morphological criteria are generally insufficient for recognition of these axons. The chapter outlines the materials and methods studied in the subject study. It analyzes the results regarding uptake and storage of biogenic amines, such as 3H-labeled norepinephrine, 3H-labeled epinephrine and dopamine, 3H-labeled DOPA, 3H-labeled normetanephrine, in postganglionic neurons under normal conditions. The chapter then discusses the effect of some drugs—for example, pheniprazine, which is an inhibitor of monoamine oxidase; reserpine; and reserpine + pheniprazine—on the uptake and storage of radioactive monoamines. A striking effect of pheniprazine on the accumulation of labeled biogenic amines was found in the superior cervical ganglion in animals that received norepinephrine- 3H or dopamine- 3H. The chapter further highlights the observations regarding the uptake and storage of certain biogenic amines in the different parts of the sympathetic neuron that were made in the present study.
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