Stoichiometry of net sodium and potassium fluxes mediated by the Na-K-Cl co-transport system in ferret red cells.

Abstract

The bumetanide-sensitive Na-K-Cl co-transport system in ferret red cells produces net movement of 1Na:1K. Tracer studies have misleadingly suggested a stoichiometry of 2Na:1K probably because the transporter mediates substantial Na-Na exchange in these cells.