Abstract
1–10 μM Cu 2+, Ag +, and Au 3+ were found to stimulate rat liver mitochondrial protein synthesis in vitro. Cu 2+ and Ag + also produced an increase in mitochondrial volume (“swelling”). Thus, thyroid hormones and their analogs are not unique, as suggested previously (Buchanan, J.L., Primack, M.P. and Tapley, D.F. (1970) Endocrinology 87, 993–999), in stimulating both mitochondrial protein synthesis and swelling. Furthermore, the data suggest a role for Cu 2+ in the regulation of mitochondrial protein synthesis.
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