Abstract
It has previously been shown that blocking 5-HT1A receptors unmasks an inhibitory action of the selective 5-hydroxytryptamine (5-HT) re-uptake inhibitor citalopram on male rat ejaculatory behaviour. This paper reports that subcutaneous (s.c.) administration of the selective 5-HT re-uptake inhibitor citalopram (10 mgkg−1) facilitated ejaculatory behaviour in male Wistar rats treated with the 5-HT1B receptor antagonist isamoltane (4 mgkg−1, s.c.), whereas neither citalopram nor isamoltane alone had any effect. It is concluded that citalopram possesses an inhibitory action on male rat ejaculatory behaviour, and that this inhibition normally is balanced by a facilitatory action mediated via 5-HT1A receptors.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
