Abstract
The previous studies on the anxiety-like behaviour in rats by using elevated plus maze and open field have provided rather unequivocal results because they obtained data at different times of the day. These studies have never investigated the effects of the different times of day in a single research paradigm even though the results of such studies are generally attributed to the different measurement times. Thus, we aimed to examine the effects of the time of the day and the pinealectomy on anxiety-like behaviour in male Wistar albino rats by using elevated plus maze and open field in this study. Experiments were performed with control and pinealectomy groups at the four different time points (6:00, 12:00, 18:00 and 24:00 hr; LD 12:12, lights on at 6:00 h and off at 18:00 h). In open field, the main effect of the measurement time was significant on the total distance travelled, the mobility and the velocity. In elevated plus maze, the main effect of the measurement time was significant on the total distance travelled, the total entry to closed arms and mobility. The main effect of the pinealectomy was insignificant on all of the measured parameters in both open field and elevated plus maze except for the total entry to closed arms in elevated plus maze. The results of the present study showed for the first time that the time of the day when the measurements are performed is important on the anxiety-like behaviour of the Wistar albino rats.
Published Version
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