Abstract
To determine the bulk drug powder particle size in pharmaceutical preparations, the quantitative correlation between the absorption peak intensity in Fourier-transformed powder diffuse reflectance infrared (FT-IR) spectra and the particle size of phenytoin powders obtained by pin- or ball-mill grinding was investigated. Absorption peak intensity of phenytoin powders increased with decrease in mean particle size (D). The relationships between the FT-IR absorbance at 1724 cm−1 and the specific surface area (Sw) obtained by the BET N2 gas absorption method of ground samples showed straight lines, indicating that the absorbance followed equation 1: log (I0/I) = K1/D = K2Sw (1) where I0 and I are intensities of the incident and transmitted light, respectively, and K1 and K2 are constants. Both relationships obtained from the pin- or ball-mill-ground samples gave linear plots, and the slopes were not significantly different.
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