Abstract
To determine the bulk powder particle size of phenytoin in pharmaceutical preparations, the quantitative correlation between the absorption peak intensity in infrared Fourier-transformed (FT-IR) spectra and the particle size of drug in mixed powders was investigated. The relationships between the FT-IR absorbance at 1724 cm−1 and the specific surface area (Sw) obtained by the N2 gas adsorption method or the reciprocal of mean particle size (D50) obtained by particle counting of ground phenytoin samples, showed straight lines, indicating that the absorbance followed equation 1: log (I0/I) = K1/d = K2Sw (1) where I0 and I are intensities of the incident and transmitted light, respectively, d is the cube's edge (of the particle) and K1 and K2 are constants. The relationship between the absorbance and Sw or the reciprocal of D50 of the bulk drug in the binary mixture samples gave a linear plot.
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