Abstract
The light stability, wet stability and thermal stability of the controlled-release tablets of sasanquasaponin (SQS)-casein were studied, respectively. The median lethal dose of SQS and the controlled-release tablets of SQS-casein were studied respectively. After strong light illumination the controlled-release tablets of SQS-casein for 5 days and 10 days respectively and placement the controlled-release tablets of SQS-casein for 5 days and 10 days respectively in humidity being 75±5, respectively, the release rates of the controlled-release tablets of SQS-casein meet the requirements of United States Pharmacopoeia, and the controlled-release tablets of of SQS-casein release SQS by slowness and constant in 12h. When humidity were 90±5% , the release rates of the controlled-release tablets of SQS-casein meet the requirements, but the controlled-release tablets of of SQS-casein do not release SQS by constant in 12h. When temperature were 40±2°C and 60±2°C respectively, the release rates of the controlled-release tablets of SQS-casein does not meet the requirements. The anti-high temperature and moistureproof measures are required in production, packaging, transpor-tation and storage of the controlled-release tablets of SQS-casein. The toxicity of the controlled-release tablets of SQS-casein are much lower than that of SQS.
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