Abstract
The controlled-release tablets of sasanquasaponin (SQS) were prepared by using SQS, broomcorn-stalk and lactose as the main drug and accessories. The effect of the particle size of broomcorn-stalk on release rate was studied. Kinetics equation of the controlled-release tablets of SQS releasing SQS was fitted. The thermal stability and wet stability of the controlled-release tablets of SQS were investigated. The controlled-release tablet of SQS was characterized by infrared absorption spectrum (IR) techniques. The releasing rate of the controlled-release tablets of SQS were controlled by controlling the particle size of broomcorn-stalk. Release speeds of the controlled-release tablets of SQS releasing SQS were constant. The thermal stability and wet stability of the controlled-release tablets of SQS were good. The chemical bonds were formed among SQS, broomcorn-stalk and lactose.
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