Squamous cell carcinoma simulating granuloma inguinale.

Abstract

SQUAMOUS cell carcinoma and granuloma inguinale at times resemble each other so closely that differentiation on clinical grounds alone may be impossible. Speiser1and Pund and Greenblatt2reported 4 and 2 cases, respectively, of granuloma inguinale of the cervix which were diagnosed clinically as carcinoma. Philpott3reported a case of granuloma inguinale of the penis which simulated carcinoma, the correct diagnosis not being established until Donovan bodies were demonstrated in the depths of the tissue when the granulomatous mass was excised. Chen, Greenblatt and Dienst,4in a series of 95 referred patients in whom the disease had been diagnosed as granuloma inguinale, found that 6 (6.3 per cent) actually had squamous cell carcinoma. Moore5reported a case which was clinically diagnosed as carcinoma of the penis and which was not proved to be granuloma inguinale until, after many biopsies, Donovan bodies were found. It