Abstract
Abstract Spreading depression was elicited in the squirrel monkey's cerebral cortex to determine some parameters of cortical spreading depression (CSD) in a highly encephalized but semi-lissencephalic brain. Rate of CSD propagation, as indicated by a slow potential (SP) change, was slower than in other mammals but comparable to that reported in other primates. Frontal and occipital regions of the cortex differed in terms of SP amplitude, CSD threshold, SP waveform, and seizure threshold. It was concluded that the squirrel monkey would be an excellent preparation for studying the effects of CSD upon memory functions, interhemispheric transfer, and other phenomena in a highly encephalized brain.
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