Abstract
Diabetic animal models play critical roles in the elucidation of the mechanisms of diabetes mellitus and the complications, and in the development of novel drugs as treatments. Spontaneously Diabetic Torii Lepr fa (SDT fatty) rat, established by introducing the fa allele of the Zucker fatty rat into SDT rat genome, is a new model of obese type 2 diabetes. We have investigated the characteristics of SDT fatty rats. Both male and female SDT fatty rats show overt obesity, and hyperglycemia and hyperlipidemia are observed at a young age as compared with SDT rats. With early incidence of diabetes mellitus, diabetic complications in SDT fatty rats were seen at younger ages than those in the SDT rats. Furthermore, we evaluated the pharmacological effects of anti-diabetic drugs, such as metformin, pioglitazone, and dipeptidyl peptidase-4 inhibitor on SDT fatty rats. SDT fatty rat is a useful model for analysis of metabolic disease and the evaluation of drugs related to metabolic disease.
Highlights
Diabetic animal models play critical roles in the elucidation of the mechanisms of diabetes mellitus and the complications, and in the development of novel drugs as treatments
They established a congenic line of the Spontaneously Diabetic Torii (SDT) rat by introducing the fa allele of the Zucker Fatty rat into the SDT rat genome via the Speed Congenic Method using a PCR technique with DNA markers
Blood insulin levels in SDT fatty rats were decreased with aging, but the decrease was inhibited by pioglitazonetreatment (Fig. 6E)
Summary
Type 2 diabetes mellitus is a polygenic disorder that is caused by a metabolic and/or hormonal imbalance between insulin secretion from cells and insulin sensitivity in peripheral tissues, both of which might be modified by genetic and environmental factors [1]. Based on the above concept, a novel model of obesity-related diabetes was established by Masuyama et al [3]. They established a congenic line of the Spontaneously Diabetic Torii (SDT) rat by introducing the fa allele of the Zucker Fatty rat into the SDT rat genome via the Speed Congenic Method using a PCR technique with DNA markers. This congenic strain has been maintained by intercrossing between fa-heterozygous littermates
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
