Abstract
Background: In Mexico, type 2 diabetes prevalence is 13.7%, which has a huge impact on Mexican public health. There is an urgent need to focus on the prevention of pre-diabetes to decrease the likelihood of type 2 diabetes onset. Gene variants predisposed to increase Fasting Blood Glucose (FBG) and glycosylated hemoglobin (HbA1c) levels could be helpful for prevention purposes. This study aimed to analyze the association of the G6PC2 rs560887 variant with pre-diabetes in a Mexican-Mestizo population. Methods: A cross-sectional case-control study was performed in 960 Mexican Mestizos participants. The association of G6PC2 rs560887 with pre-diabetes was analyzed by logistic regression and with Fasting Blood Glucose (FBG) and glycosylated hemoglobin (HbA1c) by linear regression. Results: The G6PC2 rs560887 variant was significantly associated with FBG (β -1.80, p=0.03), but not with HbA1c or the presence of pre-diabetes. Conclusion: The G6PC2 rs560887 loci could be a potential early marker of type 2 diabetes.
Highlights
Pre-diabetes is a reversible condition characterized by high blood glucose and/or glycosylated hemog-lobin (HbA1c), but not high enough to diagnose type-2 diabetes (T2D) [1, 2]
About 70% of patients with preDM will progress to type-2 diabetes (T2D) [2, 3], a disease whose prevalence in Mexico is 13.7% [4]
This is a cross-sectional and case-control study consisting of 960 volunteers over 45 years old, non-related, all with Mexican-Mestizo ancestry, and enrolled in the Cohort for the Study of Complex Diseases [Cohorte para el Estudio de Enfermedades Complejas], carried out at the Hospital Regional Lic
Summary
Pre-diabetes (pre-DM) is a reversible condition characterized by high blood glucose and/or glycosylated hemog-lobin (HbA1c), but not high enough to diagnose T2D (glucose>126 mg/dl, HbA1c≥6.5%) [1, 2]. About 70% of patients with preDM will progress to type-2 diabetes (T2D) [2, 3], a disease whose prevalence in Mexico is 13.7% [4]. There is an urgent need to focus on the treatment and prevention of preDM to decrease the likelihood of T2D onset. In Mexico, type 2 diabetes prevalence is 13.7%, which has a huge impact on Mexican public health. There is an urgent need to focus on the prevention of pre-diabetes to decrease the likelihood of type 2 diabetes onset. Gene variants predisposed to increase Fasting Blood Glucose (FBG) and glycosylated hemoglobin (HbA1c) levels could be helpful for prevention purposes. This study aimed to analyze the association of the G6PC2 rs560887 variant with pre-diabetes in a Mexican-Mestizo population
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