Abstract
Disulfiram is being used clinically as an aid in chronic alcoholism, while nicotinic acid is one of a B-complex vitamin that has cholesterol lowering activity. The aim of present study was to investigate the impact of biofield treatment on spectral properties of disulfiram and nicotinic acid. The study was performed in two groups i.e., control and treatment of each drug. The treatment groups were received Mr. Trivedi’s biofield treatment. Subsequently, spectral properties of control and treated groups of both drugs were studied using Fourier transform infrared (FT-IR) and Ultraviolet-Visible (UV-Vis) spectroscopic techniques. FT-IR spectrum of biofield treated disulfiram showed the shifting in wavenumber of C-H stretching from 1496 to 1506 cm-1 and C-N stretching from 1062 to 1056 cm-1. The intensity of S-S dihedral bending peaks (665 and 553 cm-1) was also increased in biofield treated disulfiram sample, as compared to control. FT-IR spectra of biofield treated nicotinic acid showed the shifting in wavenumber of C-H stretching from 3071 to 3081 cm-1 and 2808 to 2818 cm-1. Likewise, C=C stretching peak was shifted to higher frequency region from 1696 cm-1 to 1703 cm-1 and C-O (COO-) stretching peak was shifted to lower frequency region from 1186 to 1180 cm-1 in treated nicotinic acid. UV spectrum of control and biofield treated disulfiram showed similar pattern of UV spectra. Whereas, the UV spectrum of biofield treated nicotinic acid exhibited the shifting of absorption maxima (λmax) with respect of control i.e., from 268.4 to 262.0 nm, 262.5 to 256.4, 257.5 to 245.6, and 212.0 to 222.4 nm. Over all, the FT-IR and UV spectroscopy results suggest an impact of biofield treatment on the force constant, bond strength, and dipole moments of treated drugs such as disulfiram and nicotinic acid that could led to change in their chemical stability as compared to control.
Highlights
Disulfiram [bis(diethylthiocarbamoyl)disulphide] is an antabuse drug, being used clinically as an aid to the treatment of chronic alcoholism
The Fourier transform infrared (FT-IR) spectrum of control disulfiram sample (Figure 2a) showed the characteristic vibrational peak at 2975 cm-1 that was assigned to C-H (CH3) stretching
The FT-IR data of control disulfiram was well supported by the literature data [29]
Summary
Disulfiram [bis(diethylthiocarbamoyl)disulphide] is an antabuse drug, being used clinically as an aid to the treatment of chronic alcoholism. It is the first drug approved by US Food and Drug Administration to treat the alcohol addiction [1]. Disulfiram is reported for protozoacidal effect in vitro study [4,5]. Disulfiram has shown the reactivity to latent HIV1 expression in a primary cell model of virus latency and presently it is assessed in a clinical trial for its potential to diminish the latent HIV-1 reservoir in patients combination with antiretroviral therapy [6]
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