Abstract
The article presents the results of quantitative spectrophotometric determination of tamsulosin in a standard sample, in “Tulosin” and “Ornadex” capsules using 96% ethyl alcohol as a solvent. The relative error of determination is ±0.25% for the standard sample of tamsulosin, ±0.93% for “Tulosin” capsules, ±1.43% for “Ornadex” capsules. The proposed method of quantitative determination was validated according to the specified parameters: specificity, linearity, and accuracy. When determining the linearity of the method, the concentration of 0.4-1.6 mg was determined as the working interval of the standard sample of tamsulosin hydrochloride (r=0.994). When determining the accuracy, it was found that the working solutions prepared in 96% ethanol do not change the optical density at the absorption maxima in a short period of time (RSD = 0.622). When determining the specificity, it was found that the excipients do not interfere with the analysis.
Published Version
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