Abstract
We are the first to present results from a pilot clinical study designed for the purpose of establishing spectral mapping patterns, as a potential novel imaging assay for identifying and discriminating between functional and nonfunctional endometrial polyps in vivo. The Spectral Artificial Vision Endoscope (SAVE) was used and validated in this study. The SAVE system, adapted to a regular hysteroscope, was able to operate in several imaging modes, including color imaging, infrared imaging, narrow band imaging and spectral mapping, all acquired at a video rate and simultaneously. The spectral maps generated by the SAVE system for 28 patients with endometrial polyps displayed characteristic patterns capable of discriminating functional from nonfunctional polyps with remarkable consistency (Spearman R=0.912, p<10-6). These preliminary clinical validation results highlighted the great potential of the in vivo spectral mapping imaging modality as an adjunct tool to conventional color camera-based hysteroscopy, offering improved and quantitative diagnosis.
Highlights
Transvaginal Ultrasound (TVS) is a first-line diagnostic option in cases of Intermenstrual Bleeding (IMB), menorrhagia, Abnormal Uterine Bleeding (AUB) or PostMenopausal Bleeding (PMB), that facilitates prompt detection and possible identification of any underlying endometrial pathology [1,2]
The need for advancing hysteroscopic technology for investigating the etiopathogenesis of Endometrial polyps (EPs) in conjunction with the demand for developing novel, objective diagnostic approaches for in vivo identification and classification of EPs, has motivated our work presented in this paper
We present and discuss results from a small pilot study conducted with the purpose of acquiring and analyzing the spectral mapping patterns of functional and nonfunctional polyps with the goal of establishing additional, spectroscopy-based clinical criteria with the potential to assist clinical management decision-making
Summary
Transvaginal Ultrasound (TVS) is a first-line diagnostic option in cases of Intermenstrual Bleeding (IMB), menorrhagia, Abnormal Uterine Bleeding (AUB) or PostMenopausal Bleeding (PMB), that facilitates prompt detection and possible identification of any underlying endometrial pathology [1,2]. Endometrial polyps (EPs) are responsible for approximately. 25% of the AUB cases in both pre- and post-menopausal women [1], while IMB is by far the most common symptom associated with their presence. EPs are localized hyperplastic overgrowths of endometrial glands and stroma around a vascular core. They appear either as a sessile or as a pedunculated projection arising from the endometrial surface, with the pedunculated polyps being more common than the sessile ones [1,2]. Pedunculated EPs are attached on a thin stalk, while the sessile type is connected with a flat base to the underline endometrial mucosa and the
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