Abstract
Advancements in cancer as well as, autoimmunological or hematological conditions treatment have significantly increased the survival rate as well as, the Quality of Life (QoL) for these patients. In addition, Assisted Reproductive Techniques (ART) offers a variety of therapeutic approaches that aim towards fertility preservation and hormonal restoration after treatment. Ovarian Tissue Cryopreservation (OTC) and Ovarian Tissue Transplantation (OTT) have been proposed as an efficient alternative to reserve fertility and hormona function in cases of prepubertal young girls and women needed to be treated immediately with radiation and/or chemotherapy. In this narrative review, current scientific evidence is summarized in order to explore OTC/OTT. In addition to the qualitive presentation of our findings, we provide cumulative evidence from other published studies to demonstrate the clinical potential and limitations of these procedures.
Highlights
Over the last decades, the survival rate of patients after cancer treatment has been significantly increased [1]
Cancer survivors’ Quality of Life (QoL) has been improved significantly due to advancements in cancer treatment, as well as to the knowledge gained towards fertility preservation [2]
In order to proceed with this treatment combination one must keep in mind that these women are on the verge of Premature Ovarian Failure (POF) induction, which varies extremely from one individual to another [4]
Summary
The survival rate of patients after cancer treatment has been significantly increased [1]. There are different kind of treatments for cancer during childhood such as surgery, radiotherapy and chemotherapy. These treatments have facilitated cure, gonadal function is usually jeopardised, a fact that has a grave impact on reproductive health [6]. Fertilityrelated information on the impact of a planned treatment and information on fertility preservation should be provided in oncological and hematological care programs, and in cases of gonadotoxic treatments for treatment of benign diseases that may impair fertility. Both postponing childbearing and increased risk for malignancies with
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