Abstract
In vitro methylation of some Escherichia coli specific tRNAs by extracts from mouse normal liver and MOPC 173 plasmocytoma has been studied. The determination of the overall extent of methylation as well as of the repartition of methylated products reveals that tRNA methylases from these two sources have distinct specificities. In particular, plasmocytoma extracts seem to contain one methylase that does not exist in liver extract, the activity of which appears when tRNA Met f is used as a substrate.
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