Abstract
High speed ultracentrifugal supernatants (cytosol) from rat and rabbit uterus were prepared. The cytosols were incubated with tritiumlabeled progesterone. Cytosols from both species contained a specific progesterone binder with similar structural binding specificity. The progesterone binder in rat serum had a different binding specificity and in contrast to those in both uterine cytosols it was not sensitive to inactivation by heat or by a sulfhydryl reagent. It is concluded that the rat uterus as well as the rabbit uterus contains a specific progestogen binder albeit the levels in the rat uterus are much lower.
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