Abstract
The photoreactions between yeast-tRNA Phe and two psoralens, 8-methoxypsoralen (8-MOP) and 4′-aminomethyl-4,5′,8-trimethylpsoralen (AMT) have been investigated. It is found that AMT reacts more efficiently and with more sites on the tRNA than does 8-MOP, and that the AMT-photoreaction is inhibited by ethidium bromide and enhanced by EDTA. The results indicate that psoralens photobind to specific sites on the yeast-tRNA Phe molecule.
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