Abstract
Changes in immunological reactivity to viral and bacterial antigens may cause increased susceptibility to infectious diseases. Different levels of this condition in newborn and adult animal organisms should be based on the fact that the fetus and newborn after birth first comes into contact with the antigen, while the adult body already has partial sensitization. Chronic carrier of pathogens in animals and their influence on the spread of the infectious process is an urgent problem of modern veterinary medicine. The possibility of vaccination in newborns is limited by the presence of maternal antibodies that have an immunosuppressive effect. A high level of functional reserves of the pregnant body is important in the prevention of intrauterine infection. On the one hand, infection in the prenatal period of development affects the processes of growth and development of the fetus, on the other hand, during this period, the mother's body is isoimmunized by fetal antigens, accompanied by increased sensitivity of the body with the predominant manifestation of cellular phenomena in the absence of enhanced antibody synthesis.
Highlights
Immunological reactivity changes to viral and bacterial antigens may cause increased susceptibility to infectious diseases
To study lymphocyte receptors/markers, blood was taken from animals of test and control groups for flow cytometry method
It was found that CD4 lymphocytes were significantly less in animals in the test group (Р
Summary
Immunological reactivity changes to viral and bacterial antigens may cause increased susceptibility to infectious diseases. Different levels of this condition in newborn and adult animal organisms should be based on the fact that the fetus and newborn after birth first comes into contact with the antigen, while the adult body already has partial sensitization [1,2,3], [12,13,14,15]. Almost all newborn animals have the same passively acquired immunity, but the level of immunological load may be different. Despite many years of research on immunological reactivity, the processes of specific suppression of the immune response are insufficiently studied [10, 13, 14]
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