Abstract
Changes of immunological reactivity to viral and bacterial antigens can cause in-creased susceptibility to infectious diseases. Different levels of this changes in newborn and adult animal organisms should be based on the fetus and newborn reactivity, first coming into contact with the antigen after birth, whereas the adult organism already has partial sensitization. Chronic vectors of pathological agents in animals and their in-fluence on the spread of infectious process is a persisting problem of modern veterinary medicine. The ability to use vaccination in newborns is limited by the presence of maternal antibodies that have immunosuppres-sive effects. High level of functional abilities of preg-nant organism is important in prevention of intrauterine infection. Infection in the prena-tal period of development affects fetal growth and development processes on the one hand, and on the other - isoimmuniza-tion of the maternal organism with fetal anti-gens occurs, accompanied by increased sen-sitivity of the organism with predominant manifestation of cellular phenomena, in the absence of increased synthesis of antibodies. Given the high importance of the functional reserves of the newborn organism, the intra-uterine development and completeness of the placental barrier are important. Detection of the transportation of infectious agent in inac-tive phase during pregnancy of different gestational period should be considered from the point of view of avidity and seropositivi-ty of pregnant animals. The high variety of clinical manifesta-tions of intrauterine infection requires the development of minimally invasive methods of antenatal and intranatal prediction, which allow at the stage of pregnancy and/or child-birth to assess the presence of an agent in a very small amount as the risk of the future development of infectious disease of the fetus and newborn, or complications of the early neonatal period.
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