Evaluation of antigenic load in pregnant sows and identification of isoimmunization markers in offspring to increase productive and reproductive indicators for obtaining biologically safe organic products

Alexander Agarkov,Angelina Shulunova,Alexander Sidelnikov,Irina Nekrasova,Nikolay Agarkov,D Rudoy,N Ugrekhelidze,A Olshevskaya

doi:10.1051/e3sconf/202127302002

Alexander Agarkov, Angelina Shulunova + Show 6 more

Open Access

https://doi.org/10.1051/e3sconf/202127302002

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Abstract

Immunological aspects of the relationship in the functional system “mother-fetus” are consciously important both in the scientific and practical direction of the life of living organisms. The formation of the main parameters of isoimmunization is an equivalent aspect in relation to the basics of the formation of artificial tolerance mechanisms. Changes in immunological reactivity to viral and bacterial antigens may cause increased susceptibility to infectious diseases. Different levels of this condition in newborn and adult animal organisms should be based on the fact that the fetus and newborn after birth first comes into contact with the antigen, while the adult body already has partial sensitization. Chronic carrier of pathogens in animals and their influence on the spread of the infectious process is an urgent problem of modern veterinary medicine. The possibility of vaccination in newborns is limited by the presence of maternal antibodies that have an immunosuppressive effect.The immunological relationship between the fetal mother’s body in a non-inbred population should be considered in two aspects: the effects caused by maternal antigens in the fetus; the effect of fetal antigens on the mother’s body. Level of functional reserves of the pregnant body is important in the prevention of intrauterine infection.

Highlights

Productive animal husbandry has large losses of livestock in the process of its breeding and operation
The possibility of vaccination in newborns is limited by the presence of maternal antibodies that have an immunosuppressive effect.The immunological relationship between the fetal mother's body in a noninbred population should be considered in two aspects: the effects caused by maternal antigens in the fetus; the effect of fetal antigens on the mother's body
It is important to find out the reasons for such significant losses

Summary

Introduction

Productive animal husbandry has large losses of livestock in the process of its breeding and operation. Significant losses (young animals of early age) are caused by violation of the conditions of the intrauterine period of development [1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16]. They are accompanied by the birth of offspring with signs of reduced viability, high morbidity and mortality. The problem of effective assessment of immunological reactivity in the functional system “mother-fetus-newborn” becomes relevant >4-17@

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