Abstract
Abstract Aims This retrospective observational study from a tertiary hepatobiliary centre sought to establish patterns in presentation and subsequent stage-dependent management and survival outcomes of gallbladder cancer (GBC) over a 20-year period. We also looked at recurrence rates and utilisation of chemotherapy in the adjuvant and palliative settings. Methods All cases of GBC between 2001 and 2021 were identified through clincial coding and locally maintained database. Relevant demographic, staging, management and outcomes information was gathered via electronic records. Patients with incomplete data were excluded. Results Conclusion Out study provides a detailed picture of GBC incidence, management, and prognosis in England. GBC suffers from dismal survival outcomes due to advanced stage at presentation. T-stage has the strongest impact on survival since it determines the treatment offered. A significant proportion of patients are neither suitable for surgery due to locally advanced or mestatic disease, nor chemotherapy mostly due to poor performance status. R1 resection and post-operative recurrence pose additional problems in terms of long-term survival.
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