Abstract
We have evaluated the protective effect of sophoridine and dexmedetomidine alone and in combination against lipopolysaccharides induced myocardial dysfunction. Mitochondrial reactive oxygen species, malondialdehyde and superoxide dismutase in the myocardial tissue and inflammatory cytokines served as markers of oxidative stress and mitochondrial dysfunction. Data of the study suggest that myocardial function was improved with sophoridine alone and in combination with dexmedetomidine in septic mice. Also, there was reduction in the expression of NADPH oxidase 2, NADPH oxidase 4, p-Extracellular signal-regulated kinase/Extracellular signal-regulated kinase, p-P38/P38 and caspase-3 protein in the myocardial tissues of sophoridine-treated group than sepsis group of mice. In conclusion, data of the report reveals that sophoridine alone and in combination with dexmedetomidine shows synergistic effect against the management of sepsis induced myocardial injured mice by modulating the expression of NADPH oxidase 2.
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