Abstract

Research ArticleOpen AccessSome pharmacologic and toxicologic effects of di-2-ethylhexyl phthalate (DEHP) and other plasticizers. R J Rubin, and R J Jaeger R J Rubin Search for more papers by this author and R J Jaeger Search for more papers by this author Published:1 January 1973https://doi.org/10.1289/ehp.730353Cited by:39AboutSectionsPDF ToolsDownload CitationsTrack Citations ShareShare onFacebookTwitterLinked InReddit FiguresReferencesRelatedDetailsCited by Mariana M, Feiteiro J and Cairrao E (2017) Cardiovascular Response of Rat Aorta to Di-(2-ethylhexyl) Phthalate (DEHP) Exposure, Cardiovascular Toxicology, 10.1007/s12012-017-9439-6, 18:4, (356-364), Online publication date: 1-Aug-2018. Mariana M, Feiteiro J, Verde I and Cairrao E (2016) The effects of phthalates in the cardiovascular and reproductive systems: A review, Environment International, 10.1016/j.envint.2016.07.004, 94, (758-776), Online publication date: 1-Sep-2016. Posnack N (2014) The Adverse Cardiac Effects of Di(2-ethylhexyl)phthalate and Bisphenol A, Cardiovascular Toxicology, 10.1007/s12012-014-9258-y, 14:4, (339-357), Online publication date: 1-Dec-2014. Gillum N, Karabekian Z, Swift L, Brown R, Kay M and Sarvazyan N (2009) Clinically relevant concentrations of di (2-ethylhexyl) phthalate (DEHP) uncouple cardiac syncytium, Toxicology and Applied Pharmacology, 10.1016/j.taap.2008.12.027, 236:1, (25-38), Online publication date: 1-Apr-2009. Glue C, Millner A, Bodtger U, Jinquan T and Poulsen L (2002) In vitro effects of monophthalates on cytokine expression in the monocytic cell line THP-1 and in peripheral blood mononuclear cells from allergic and non-allergic donors, Toxicology in Vitro, 10.1016/S0887-2333(02)00082-6, 16:6, (657-662), Online publication date: 1-Dec-2002. Dees J, Gazouli M and Papadopoulos V (2001) Effect of mono-ethylhexyl phthalate on MA-10 Leydig tumor cells, Reproductive Toxicology, 10.1016/S0890-6238(01)00110-1, 15:2, (171-187), Online publication date: 1-Mar-2001. Prasad M and Cinti D (1986) Effect of the peroxisomal proliferator di(2-ethylhexyl)phthalate on component reactions of the rat hepatic microsomal fatty acid chain elongation system and on other hepatic lipogenic enzymes, Archives of Biochemistry and Biophysics, 10.1016/0003-9861(86)90501-1, 248:2, (479-488), Online publication date: 1-Aug-1986. Russell D, McDuffie B and Fineberg S (2008) The effect of biodegradation on the determination of some chemodynamic properties of phthalate esters, Journal of Environmental Science and Health . Part A: Environmental Science and Engineering, 10.1080/10934528509375268, 20:8, (927-941), Online publication date: 1-Dec-1985. Tavares I, Bennett A, Gaffen J, Morris H and Taylor G (1984) The biological activities of phthalate esters on rat gastric muscle, European Journal of Pharmacology, 10.1016/0014-2999(84)90738-6, 106:2, (449-452), Online publication date: 1-Nov-1984. (2016) 3 Final Report on the Safety Assessment of Dioctyl Adipate and Diisopropyl Adipate, Journal of the American College of Toxicology, 10.3109/10915818409010517, 3:3, (101-130), Online publication date: 1-May-1984. Thomas J, Thomas M and Gangolli S (2008) Biological Effects of DI-(2-Ethylhexyl) Phthalate and Other Phthalic Acid Esters, CRC Critical Reviews in Toxicology, 10.3109/10408448409023761, 13:4, (283-317), Online publication date: 1-Jan-1984. Russell D and McDuffie B (2006) Analysis for Phthalate Esters in Environmental Samples: Separation from PCB's and Pesticides Using Dual Column Liquid Chromatography, International Journal of Environmental Analytical Chemistry, 10.1080/03067318308071916, 15:3, (165-183), Online publication date: 1-Jul-1983. Pereira G, Herold R, Ziegler M, Roth K, Jacobowski D and Boettcher M (2016) Sustained Flexibility in Infant Feeding Tubes Containing Nonmigrating Plasticizer, Journal of Parenteral and Enteral Nutrition, 10.1177/014860718200600164, 6:1, (64-67), Online publication date: 1-Jan-1982. Agarwal D, Agarwal S and Seth P (1982) Interaction of di-(2-ethylhexyl) phthalate with the pharmacological response and metabolic aspects of ethanol in mice, Biochemical Pharmacology, 10.1016/0006-2952(82)90621-9, 31:21, (3419-3423), Online publication date: 1-Nov-1982. Seth P (2018) Hepatic effects of phthalate esters., Environmental Health Perspectives, 45, (27-34), Online publication date: 1-Nov-1982.Bell F (2018) Effects of phthalate esters on lipid metabolism in various tissues, cells and organelles in mammals., Environmental Health Perspectives, 45, (41-50), Online publication date: 1-Nov-1982. Takahashi T, Tanaka A and Yamaha T (1981) Elimination, distribution and metabolism of di-(2-ethylhexyl)adipate (deha) in rats, Toxicology, 10.1016/0300-483X(81)90085-8, 22:3, (223-233), Online publication date: 1-Jan-1981. Zuccato E, Cantoni R, Bidoli F, Rizzardini M, Salmona M, Caccia S, Gambazza K, Bartos̆ek I, Guaitani A, Marcucci F and Mussini E (1980) Effects of chronic treatment with DI-(2-ethylhexyl) phthalate on rat liver microsomal activities, Toxicology Letters, 10.1016/0378-4274(80)90102-2, 6:1, (51-58), Online publication date: 1-Jun-1980. Bally M, Opheim D and Shertzer H (1980) Di-(2-ethylhexyl) phthalate enhances the release of lysosomal enzymes from alveolar macrophages during phagocytosis, Toxicology, 10.1016/0300-483X(80)90037-2, 18:1, (49-60), Online publication date: 1-Jan-1980. Lawrence W (2008) Phthalate Esters: The Question of Safety, Clinical Toxicology, 10.3109/15563657808988230, 13:1, (89-139), Online publication date: 1-Jan-1978. Daniel J (2008) Toxicity and Metabolism of Phthalate Esters, Clinical Toxicology, 10.3109/15563657808988236, 13:2, (257-268), Online publication date: 1-Jan-1978. (1978) What is the Toxicological Importance of the Liberation of Phthalates from Plastic Containers into Blood, its Components and Derivatives?, Vox Sanguinis, 10.1111/j.1423-0410.1978.tb02476.x, 34:4, (244-254), Online publication date: 1-Apr-1978. Thomas J, Darby T, Wallin R, Garvin P and Martis L (1978) A review of the biological effects of di-(2-ethylhexyl) phthalate, Toxicology and Applied Pharmacology, 10.1016/0041-008X(78)90024-8, 45:1, (1-27), Online publication date: 1-Jul-1978. Aronson C, Serlick E and Preti G (1978) Effects of di-2-ethylhexyl phthalate on the isolated perfused rat heart, Toxicology and Applied Pharmacology, 10.1016/0041-008X(78)90295-8, 44:1, (155-169), Online publication date: 1-Apr-1978. Guess W (2008) Safety Evaluation of Medical Plastics, Clinical Toxicology, 10.3109/15563657809149586, 12:1, (77-95), Online publication date: 1-Jan-1978. Srivastava S, Agarwal D and Seth P (1977) Effect of di-2-ethylhexyl phthalate on the activity of succinic dehydrogenase and adenosine triphosphatase of some vital organs of rat, Toxicology, 10.1016/0300-483X(77)90061-0, 7:2, (163-168), Online publication date: 1-Apr-1977. Takeshita R, Takabatake E, Minagawa K and Takizawa Y (1977) Micro-determination of total phthalate esters in biological samples by gas-liquid chromatography, Journal of Chromatography A, 10.1016/S0021-9673(00)83487-1, 133:2, (303-310), Online publication date: 1-Mar-1977. Tomita I, Nakamura Y and Yagi Y (1977) Phthalic acid esters in various foodstuffs and biological materials, Ecotoxicology and Environmental Safety, 10.1016/0147-6513(77)90043-4, 1:2, (275-287), Online publication date: 1-Sep-1977. Stern I, Miripol J, Izzo R and Lueck J (1977) Physicochemical aspects of the extraction in blood and the disposition in rats of di-(2-ethylhexyl) phthalate plasticizer, Toxicology and Applied Pharmacology, 10.1016/S0041-008X(77)80006-9, 41:3, (507-522), Online publication date: 1-Sep-1977. (2008) Short Communications, Xenobiotica, 10.3109/00498257709036243, 7:1-2, (93-115), Online publication date: 1-Jan-1977. Booth G, Rhees R, Petersen R and Larsen J (1976) METABOLISM AND AUTORADIOGRAPHIC LOCALIZATION OF DI-2-ETHYLHEXYL PHTHALATE (DEHP) IN MICE AND A MODEL ECOSYSTEM Mechanisms of Toxicity and Metabolism, 10.1016/B978-0-08-020544-1.50029-7, (225-235), . SETH P (1976) SOME BIOCHEMICAL AND PHARMACOLOGIC EFFECTS OF DI-2-ETHYLHEXYL PHTHALATE (DEHP). Mechanisms of Toxicity and Metabolism, 10.1016/B978-0-08-020544-1.50030-3, (237-245), . Lawrence W, Malik M, Turner J, Singh A and Autian J (1975) A toxicological investigation of some acute, short-term, and chronic effects of administering di-2-ethylhexyl phthalate (DEHP) and other phthalate esters, Environmental Research, 10.1016/0013-9351(75)90043-2, 9:1, (1-11), Online publication date: 1-Feb-1975. Schulz C, Rubin R and Hutchins G (1975) Acute lung toxicity and sudden death in rats following the intravenous administration of the plasticizer, di(2-ethylhexyl)-phthalate, solubilized with tween surfactants, Toxicology and Applied Pharmacology, 10.1016/0041-008X(75)90077-0, 33:3, (514-525), Online publication date: 1-Sep-1975. Lake B, Gangolli S, Grasso P and Lloyd A (1975) Studies on the hepatic effects of orally administered di-(2-ethylhexyl) phthalate in the rat, Toxicology and Applied Pharmacology, 10.1016/0041-008X(75)90226-4, 32:2, (355-367), Online publication date: 1-May-1975. Gough K and Gesser H (1975) The extraction and recovery of phthalate esters from water using porous polyurethane foam, Journal of Chromatography A, 10.1016/S0021-9673(01)98941-1, 115:2, (383-390), Online publication date: 1-Dec-1975. Daniel J and Bratt H (1974) The absorption, metabolism and tissue distribution of di(2-ethylhexyl) phthalate in rats, Toxicology, 10.1016/0300-483X(74)90042-0, 2:1, (51-65), Online publication date: 1-Mar-1974. Rowland I (1974) Metabolism of Di-(2-ethylhexyl) phthalate by the contents of the alimentary tract of the rat, Food and Cosmetics Toxicology, 10.1016/0015-6264(74)90001-7, 12:3, (293-302), Online publication date: 1-Jun-1974. Campioli E, Batarseh A, Li J, Papadopoulos V and Appanna V (2011) The Endocrine Disruptor Mono-(2-Ethylhexyl) Phthalate Affects the Differentiation of Human Liposarcoma Cells (SW 872), PLoS ONE, 10.1371/journal.pone.0028750, 6:12, (e28750) Vol. 3January 1973Metrics About Article Metrics Publication History Originally published1 January 1973Published in print1 January 1973 Financial disclosuresPDF download License information EHP is an open-access journal published with support from the National Institute of Environmental Health Sciences, National Institutes of Health. All content is public domain unless otherwise noted. Note to readers with disabilities EHP strives to ensure that all journal content is accessible to all readers. However, some figures and Supplemental Material published in EHP articles may not conform to 508 standards due to the complexity of the information being presented. If you need assistance accessing journal content, please contact [email protected]. Our staff will work with you to assess and meet your accessibility needs within 3 working days.

Full Text
Published version (Free)

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call