Some biochemical parameters and acute phase proteins in goats with pregnancy toxemia

Abstract

The present study investigated the levels of acetylcholinesterase, tumor necrosis factor-α (TNF), paraoxonase (PON1), haptoglobin (HPT), serum amyloid A (SAA), beta-hydroxybutyric acid (BHBA), non-esterified fatty acid (NEFA), glucose, total protein, cholesterol, and triglyceride in Saanen goats with pregnancy toxemia. The animal material included Saanen goats aged 2-5 years. The study was conducted on a total of 20 Saanen goats: 10 pregnant and 10 healthy animals. After clinical examination, 10 goats with BHBA levels of more than 1.5 mmol/L of blood were included in the pregnancy toxemia group, and 10 healthy goats with BHBA levels of less than 1 mmol/L were included in the control group. There were no significant differences between the total protein, cholesterol, and triglyceride levels in the two groups. It was determined that, while the glucose level was low in the goats with pregnancy toxemia, BHBA, NEFA, acetylcholinesterase, tumor necrosis factor-α, paraoxonase, serum amyloid A, and haptoglobin levels were higher than they were in the healthy goats. In conclusion, it appears that ACHE, TNFa, PON, SAA, and HPT may be useful as additional indicators in the diagnosis of pregnancy toxemia and in the development of methods for its prevention.