Abstract
In the present research work mixed hydrotropic solubilization phenomenon is used to enhance the solubilization of poorly water-soluble drugs. Bulk drug samples were identified by the observed IR spectra and the melting points determination. Sodium benzoate, niacinamide, and urea are the hydrotropes were selected for the solubility enhancement of drugs Solubility enhancement ratios for selected poorly water-soluble drugs were determined. Results showed that remarkable increase in aqueous solubility of Miconazole in presence of large concentration of hydrotropes. Marketed Miconazole tablets determined by spectrophotometric analysis using hydrotropic solubilization techniques. Validation of the proposed analysis methods is confirmed by satisfactorily low values of statistical parameters viz., standard deviation, percent coefficient of variation and standard error. Keywords : Solubility enhancement, hydrotropes, Solid dispersion, Miconazole.
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