Abstract
In the present investigation, the poorly water-soluble drug, salicylic acid has been solubilized using 0.5 M ibuprofen sodium and 2.0 M sodium salicylate solution as hydrotropic agents for the titrimetric analysis precluding the use of organic solvents. Both hydrotropes are economic and pollution-free. The mean percent estimation of salicylic acid estimated in bulk sample by Indian Pharmacopoeial method is 98.78%. The mean percent estimation by ibuprofen sodium method and sodium salicylate method are 99.25% and 98.82%, respectively. The results of analysis by the proposed method are very close to the results of analysis by the standard method. This confirms the accuracy of the proposed method. The proposed method was validated statistically by low values of statistical parameters viz. standard deviation, percent coefficient of variation and standard error. The proposed method is new, accurate, simple and economic.
Highlights
The poorly water-soluble drug, salicylic acid has been solubilized using 0.5 M ibuprofen sodium and 2.0 M sodium salicylate solution as hydrotropic agents for the titrimetric analysis precluding the use of organic solvents
The primary objective of this study was to preclude the use of organic solvent and to employ hydrotropic solubilizing agents, ibuprofen sodium and sodium salicylate, which are economic
IPM refers to Indian Pharmacopoeial method, ISM refers to ibuprofen sodium method and SSM refers to sodium salicylate method; (n=4)
Summary
The poorly water-soluble drug, salicylic acid has been solubilized using 0.5 M ibuprofen sodium and 2.0 M sodium salicylate solution as hydrotropic agents for the titrimetric analysis precluding the use of organic solvents. The Indian Pharmacopoeial method of titrimetric analysis of salicylic acid uses an organic solvent, ethanol for the solubilization of the drug. The primary objective of this study was to preclude the use of organic solvent and to employ hydrotropic solubilizing agents, ibuprofen sodium and sodium salicylate, which are economic. Enhancement of solubility of salicylic acid in 0.5 M ibuprofen sodium solution and 2.0 M sodium salicylate solution was more than 12-folds and 6- folds respectively (as compared to solubility in distilled water)
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