Abstract
The solubility data of rofecoxib in various mass fraction compositions of cosolvents (glycerol, propylene glycol, and ethanol) + water and surfactants (Span 20, Tween 80, and sodium lauryl sulfate) + water at (298.15, 303.15, and 308.15) K are presented. The analysis of rofecoxib was done by high-performance liquid chromatography. The solubility of rofecoxib increased with increasing mass fraction of cosolvents and surfactants at (298.15, 303.15, and 308.15) K. For ethanol + water mixtures, the solubility of rofecoxib was higher when compared to the glycerol + water and propylene glycol + water mixtures. The solubilization power of glycerol, propylene glycol, and ethanol at (298.15, 303.15, and 308.15) K was 0.81, 0.87, and 0.88; 2.2, 2.3, and 2.4; and 3.4, 3.6, and 3.8, respectively. In case of surfactants, sodium lauryl sulfate exhibited higher solubilizing efficiency at (298.15, 303.15, and 308.15) K than Span 20 and Tween 80.
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