Solubility and Modeling of Hesperidin in Cosolvent Mixtures of Ethanol, Isopropanol, Propylene Glycol, and n-Propanol + Water

Abstract

Equilibrium solubility of hesperidin in aqueous solutions of ethanol, isopropanol, propylene glycol, and n-propanol was determined by static technique at temperatures ranging from 293.15 to 333.15 K under p = 101.1 kPa. The hesperidin solubility increased monotonously with the increase in mass fraction of ethanol isopropanol, propylene glycol, and n-propanol and temperature. At the same composition of alcohol and temperature, the mole fraction solubility of hesperidin was largest in propylene glycol + water among the four cosolvent mixtures. The solubilities of hesperidin were correlated with Jouyban–Acree model, Apelblat–Jouyban–Acree model, and van’t Hoff–Jouyban–Acree model. The obtained average relative deviations were less than 2.38%.