Abstract
The solubility of citalopram hydrobromide in ethanol mixed with cosolvent toluene and ethyl acetate was measured at temperatures from 283.15 to 318.15 K to study the solubility improvement of the poorly soluble drug. The solubility increases with increasing cosolvent mass fraction w to a maximum value at w = 0.6 and then decreases. The Jouyban-Acree model and CNIBS/R-K model are applied to correlate the solubility. All the values of RMSD and RAD are no more than 5.36 × 10−2 and 5.72 × 10−4, respectively. Apparent thermodynamic analysis indicate that the dissolution is an endothermic, spontaneous and entropy driven process. More importantly, the effect of cosolvent on the dissolution process for citalopram hydrobromide is an important aspect of its purification, recrystallization and clinical application.
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