Abstract
The effect of cosolvent on the dissolution process for piperine is an important aspect of its purification, recrystallization and clinical application. In this work, the solubility profile of piperine in acetone + ethanol and ethyl acetate + ethanol binary solvents with acetone / ethyl acetate mass fraction ranging from 0 to 1 at various temperatures ranging from 278.15 K to 318.15 K was measured and evaluated using Jouyban-Acree model and CNIBS/R-K model. The results showed that the solubility of piperine increased firstly and then decreased with the increasing mass fraction of acetone / ethyl acetate at a certain temperature. The solute–solvent interaction was analyzed by solubility parameters. The values of RAD show that the CNIBS/R-K model is more satisfactory to correlate the experimental data. Furthermore, apparent thermodynamic analysis indicate that the dissolution is an endothermic and entropy driven process.
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